Chloride channels as drug targets
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چکیده
منابع مشابه
TRP channels as drug targets.
Ca2+ channel antagonists acting on electrically-excitable cells have proved to be valuable therapeutic agents. The discovery of such agents and the identification of their molecular target resulted from the investigation of unexpected actions of known pharmacological agents. Ca2+ influx through receptor-operated channels in electrically non-excitable cells such as leukocytes is also functionall...
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New compounds are needed to treat parasitic nematode infections in humans, livestock and plants. Small molecule anthelmintics are the primary means of nematode parasite control in animals; however, widespread resistance to the currently available drug classes means control will be impossible without the introduction of new compounds. Adverse environmental effects associated with nematocides use...
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ژورنال
عنوان ژورنال: Nature Reviews Drug Discovery
سال: 2008
ISSN: 1474-1776,1474-1784
DOI: 10.1038/nrd2780